Multivesicular bodies: co-ordinated progression to maturity
نویسندگان
چکیده
منابع مشابه
Multivesicular bodies
theoreticians in developmental biology, as mainstream opinion held that one had to clone the genes involved and isolate the corresponding molecules — and that development would then be understood. The interest in theories was correspondingly low. At this time, the fascinating and beautiful patterns on shells were for me an inspiring looking glass to study the richness of patterns that can emerg...
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Two key events in Wnt signal transduction, receptor endocytosis and inactivation of Glycogen Synthase Kinase 3 (GSK3), remain incompletely understood. Taelman et al. (2010) discover that Wnt signaling inactivates GSK3 by sequestering the enzyme in multivesicular bodies, thus linking these two events and providing a new framework for understanding Wnt signaling.
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Although RII protein kinase A (PKA) regulatory subunits are constitutively localized to discrete cellular compartments through binding to A-kinase-anchoring proteins (AKAPs), RI subunits are primarily diffuse in the cytoplasm. In this paper, we report a novel AKAP-dependent localization of RIα to distinct organelles, specifically, multivesicular bodies (MVBs). This localization depends on bindi...
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Genetic studies have identified a number of proteins required for the internalization of biosynthetic and endocytic cargo proteins transported to the multivesicular body (MVB). We have developed a cell-free reaction that recapitulates the internalization of a yeast biosynthetic membrane cargo protein, carboxypeptidase S (CPS), into the interior of an endosome. A recombinant form of CPS containi...
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Powdery mildew fungi infect a wide variety of monocots and dicots, forming feeding structures called haustoria in epidermal cells of their hosts (reviewed in Eichmann and Hückelhoven, 2008). In response to these fungi, plants reinforce their cell walls with callose-rich appositions, called papillae, at the site of attack. Proteins involved in two pathways of penetration resistance have been ide...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2008
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2008.04.001